Causes of Overweight

Causes of Overweight / Obesity
LOOI, Ji Keon

Overview
•Inherited
•Environment
•Psychological
•Endocrine
•Medications

It runs in the family!!!
•Determination of body composition is polygenic (>600 genes)
•Heritability of BMI is relatively high (50-90%)
•Genetic predisposition to obesity is proven
•Monogenic forms of obesity are relatively rare
•Metabolic syndrome
–high cholesterol & high blood pressure
•gene mutations in the mitochondria
•Shared familial characteristics in the environment
–Food preferences
–Lifestyle factors

It’s everywhere!!!
•Fast food / junk food
•Busy work
•Sedentary lifestyle – couch potatoes!
•Inadequate physical exertion

Psychological factors
•Food <-------> emotion
•Depression and stress lead to eating disorder, hence obesity.
Endocrine
•Cushing’s Syndrome – excess cortisol stimlating appetite
•Hypothyroidism – low basal metabolic rate
•Impeded leptin production – inability cells to signal satiety
•Insulinoma
•Polycystic Ovarian Syndrome


“Fattening” Medications
•Note: May have different properties in different individuals.

•Lithium for manic bipolar disorders
•Cortisone for rheumatism and allergies
•Anti-seizure medicines (Valproate)
•Antidepressants
•Migraine medicines (Sandomigrin, Ergenyl, Trypizol)
•Oestrogen (Follimin, Follinett, Neovletta)
•Insulin for type 2 diabetes (Insulatard, Humulin, Actrapid)
•Breast cancer medicines (Nolvadex, Tamoxifen)
•Beta blockers (Inderal, Cardura)
*Incomplete List

Have a nice Raya!And not to overeat!

•Thank you