PCL Group :D: Biochemistry Profile

Hi all, I tried searching the internet for general information about the definition and interpretion of a biochemistry profile in general but there were not many good sites around. Nonetheless, I have made sense of what little I found and tried to come up with something coherent. Hope it makes sense to you.

Generally, a biochemistry profile refers to a report that shows biochemical properties (pH, osmolarity, composition, concentration of chemical substances) of bodily fluids like blood and urine.

It is used in the diagnosis and treatment of certain liver, heart and kidney diseases, acid-base imbalance, lipid metabolism disorders, endocrine disorders, metabolic or nutritional disorders.

Some examples of chemical substances measured in the blood (normal values):
• Bicarbonate (HCO3) (23-33mMol/ L)
• Blood Urea Nitrogen (BUN) (8-20mg/L)
• Calcium (8-10mg/dL)
• Cholesterol (<155mg/dl)
-Some examples of chemical substances measured in urine.
• Protein
• Glucose
• Nitrites
• Ketones
• Haemoglobin
• Bilirubin
• Urobilirubin

Let’s analyze Hazim’s biochemistry profile:

• Na (135-145mMol/dL) 119 - low
• K (3.5-5.0mMol/dL) 3.6 - normal
• Cl (95-105mMol/dL) 98 - normal
• HCO3 (24-30mMol/dL) 22 - slightly low
• Glucose (3.5-5.5mMol/dL) 8.0 - high
• Urea (2.5-6.7mMol/dL) 10.0 - high
• Creatinine (60-120 uMol/L) - normal

Important Notes:

Compare results to chart below.
Come up with a list of differential diagnosis.
Correlate results differential diagnosis with patient’s history. Is it likely to happen?
More tests are usually needed to confirm the diagnosis.
Biochemistry profile cannot tell us the whole picture.